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Closed Projects

About

We are developing novel methods to investigate interactions between biomolecules, employing electrically switchable DNA layers, nanoparticle plasmonics, and solid state nanopore sensors. During the course of the project, we were able to lay the scientific foundations for the controlled electrical manipulation of DNA molecules on surfaces, which constitute the basis for the “switchsense” principle. The application of the switchsense method for the detection of DNA and proteins was published in high-impact journals such as PNAS, Nano Letters, JACS, and others. Special attention was given to the unique feature of the switchsense method, namely, the molecular dynamics analysis of the DNA switching process, from which the size or shape of the bound target molecule can be inferred. In 2010 we realized a time-resolved method to measure the switching dynamics on the sub-microsecond timescale, which was an important advancement with respect to the analysis of proteins on a chip. A corresponding patent was filed recently, which adds to the ca. 20 previous patent applications concerning the switchsense technology.

Along with scientific investigations concerning the electrical actuation of DNA layers, we undertook major efforts to design and build various prototypes of electro-optical measurement devices (see figure of a recent version). Additionally, microchip featuring 24 microelectrodes was designed and the chemical functional with several protein receptors was developed.

 

01-01-1970
IGSSE setup of interdisciplinary research in project teams
16.05.17

Apply now: 12th call for proposals

IGSSE supports up to 10 new project teams

Call closes 2 July 2017

11.06.17

Apply now: IGSSE travel grant for ICCE 2017

28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017

08.06.17

IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

14.05.17

Climate-KIC: Join the PhD Catapult

Two-week thematic summer schools across Europe

04.05.17

IAS Symposium: Selected topics in science and technology

8-10 May 2017, IAS Building, Garching Campus

02.05.17

IAS Coffee Talk with PTL Florian Praetorius

3 May 2017, 1 pm, TUM IAS Building, Garching Campus

23.02.16

10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Friday, 09. June 2017
Workshop: Standing up for science
9 June 2017, 9am-4pm, Brussels
Apply now: McKinsey 'Forschergeist' symposium
9-11 June 2017, Berlin For doctoral researchers and postdocs!