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BioMat07 - Cell Migration Modeling

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Comprehensive Model for Cell Migration in Health and Disease Based on Novel Experimental and Computational Approaches

Cell migration, i.e., the active movement of living cells through the extracellular matrix (ECM), is essential for various physiological and pathological processes, e.g., embryonic growth, wound healing, inflammatory response, angiogenesis, and tumor metastasis. Despite this outstanding importance, however, the detailed processes involved are not fully understood. Therefore, we aim to establish a comprehensive 3D model enabling the study of individual and collective cell migration with a specific focus on the influence of physical factors such as matrix stiffness and interstitial flow. For this purpose, novel experimental and computational models and methods are developed and combined. This combination is essential for two reasons. First, experimental data are required to identify relevant phenomena to be considered in the computational model (CM), deduce realistic parameters, and validate the chosen approach. Second, the CM is needed to improve experimental design, interpret data obtained from the experimental model (EM), and test hypotheses in instances where experiments are not feasible. Due to this strong interconnection, CM and EM are developed in close cooperation. This necessity is the driving force for this proposal that will form a unique combination of experimental and computational strengths.

This project is a cooperation with Prof. Roger Kamm of MITMECHE, the department of mechanical engineering at the Massachussetts Institute of Technology/ Cambridge.

01-01-1970
IGSSE setup of interdisciplinary research in project teams
16.05.17

Apply now: 12th call for proposals

IGSSE supports up to 10 new project teams

Call closes 2 July 2017

11.06.17

Apply now: IGSSE travel grant for ICCE 2017

28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017

08.06.17

IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

14.05.17

Climate-KIC: Join the PhD Catapult

Two-week thematic summer schools across Europe

04.05.17

IAS Symposium: Selected topics in science and technology

8-10 May 2017, IAS Building, Garching Campus

02.05.17

IAS Coffee Talk with PTL Florian Praetorius

3 May 2017, 1 pm, TUM IAS Building, Garching Campus

23.02.16

10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Friday, 09. June 2017
Workshop: Standing up for science
9 June 2017, 9am-4pm, Brussels
Apply now: McKinsey 'Forschergeist' symposium
9-11 June 2017, Berlin For doctoral researchers and postdocs!