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BioMat06 - EHASOI

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The Enthesis: Nature´s Solution for a Hard-Soft Junction

The enthesis describes the anatomic site where bone and tendon join. Contractile forces of the muscle are transmitted to the bone and skeletal system. The anchorage of the tendon withstands high forces that exceed a multiple of the body weight under varying angles. The goal of the project is to investigate the microstructure and force dependent deformation of the tissue.

We will first screen for a reproducible way of labeling collagen fibers in combination with a nuclear stain. We will image how cells and collagen fibers are distributed in the enthesis and neighboring tissue in three dimensions. Here, confocal microscopy and nanoscopy (STED) will be employed to cover the range between 500 Dm down to 50 nm.

In a second step, we compare the structure of the tissue before and after force application to the tendon. From these measurements, we will gain a clearer picture of how entheses manage to stay intact and do their job under repetitive and high load applied in various angles.

From preliminary experiments we hypothesize that the tenocyte columns are surrounded by a tube of collagen fibers, which enable a very effective force transduction mechanism. This will be the basis for the development of quantitative mechanical models, which may lead to important implications for the treatment of enthesiopathies or reconstructive surgery, with improvements for the fixation of tendons to endoprosthesis. The unraveled force transduction mechanisms could also result in the development of new composite materials outside the medical field.

01-01-1970
14.02.17

IGSSE Forum 2017: Manage your career!

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

24.03.17

Workshop: Standing up for science

9 June 2017, 9am-4pm, Brussels

16.03.17

Podiumsdiskussion: Frauenförderung - Quo vadis?

17. Mai 2017, 14- 16 Uhr, Hochschule Weihenstephan-Triesdorf, Weidenbach

28.02.17

Nature paper for IGSSE team

Team EHASOI unlocks the secrets of the Achilles´ heel

24.02.17

10 new project teams for IGSSE

Supporting research across 8 TUM departments

5 international partners involved

14.02.17

IGSSE Forum 2017: Manage your career!

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Wednesday, 15. March 2017