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BioMat04 - EngCryBio

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Engineered Crystalline Biomaterials

Natural macromolecular 'machines' exploit complicated 3D scaffolds of proteins and nucleic acids to position structural features with near-atomic precision in order to fulfill their complicated tasks. These structures have inspired many researchers to design synthetic objects that achieve functionalities known today only from natural complexes. A candidate route toward achieving this goals builds on molecular self-assembly with DNA. Large, densely-packed DNA objects obtained by DNA origami methods have proven useful in applications that rest on discrete shapes fabricated to a precision of several nanometer. Yet, high resolution 3D structural information on these objects has not been reported so far, thus stalling further progress in the design of objects to meet subnanometer-precise specifications. Our aim is to combine crystallography and electron microscopy to contribute to the creation of a comprehensive picture of structure, dynamics and interactions of the origami structures during their folding pathway. Central focus is to engineer discrete DNA objects such that they become amenable to crystallization, exploring crystallization conditions, and structural analysis once crystals have become available as well as addressing the kinetics during the origami assembly. The objectives of the engineering partner of the project (Dietz) comprise the design, production, and electron microscopy analysis of synthetic DNA based objects. The science partner of the project (Groll) has extensive expertise in the characterisation, purification and crystallographic analysis of large protein complexes.

01-01-1970
IGSSE setup of interdisciplinary research in project teams
16.05.17

Apply now: 12th call for proposals

IGSSE supports up to 10 new project teams

Call closes 2 July 2017

11.06.17

Apply now: IGSSE travel grant for ICCE 2017

28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017

08.06.17

IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

14.05.17

Climate-KIC: Join the PhD Catapult

Two-week thematic summer schools across Europe

04.05.17

IAS Symposium: Selected topics in science and technology

8-10 May 2017, IAS Building, Garching Campus

02.05.17

IAS Coffee Talk with PTL Florian Praetorius

3 May 2017, 1 pm, TUM IAS Building, Garching Campus

23.02.16

10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Friday, 09. June 2017
Workshop: Standing up for science
9 June 2017, 9am-4pm, Brussels
Apply now: McKinsey 'Forschergeist' symposium
9-11 June 2017, Berlin For doctoral researchers and postdocs!