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BioMat03 - CXCR4

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Stem Cell Recruiting by Novel CXCR4 Ligands

The stimulation of stem and progenitor cell recruitment by means of activation of the chemokine receptor CXCR4 will be investigated. New, highly active CXCR4 peptoid ligands recently developed in our laboratories will be studied. These compounds, which show an affinity for CXCR4 similar or higher compared to the natural ligand, CXCL12, are expected to strongly enhance the mobilization of adult stem cells. To achieve a controlled and continuous release, new degradable hydrogels capable of immobilizing or integrating the ligands will be developed.

We will further investigate the recruitment, attachment and fate of CXCR4-positive stem cells on polymeric matrices and artificial surfaces (e.g. titanium) of implants decorated with newly developed CXCR4 ligands immobilized on the aforementioned materials by means of suitable spacer and anchoring units. As differentiation and proliferation of stem cells is expected to occur at the site of injury (implantation), enhanced and faster healing of the damaged tissue is expected. Whereas attracted mesenchymal stem cells will differentiate into osteoblasts and hence promote bone remodeling, distinct stem cell types (e.g. hematopoietic stem cells) and progenitor cells (e.g. endothelial progenitor cells) may promote neovascularization and angiogenesis and fasten wound healing and tissue regeneration.

01-01-1970
IGSSE setup of interdisciplinary research in project teams
16.05.17

Apply now: 12th call for proposals

IGSSE supports up to 10 new project teams

Call closes 2 July 2017

11.06.17

Apply now: IGSSE travel grant for ICCE 2017

28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017

08.06.17

IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

14.05.17

Climate-KIC: Join the PhD Catapult

Two-week thematic summer schools across Europe

04.05.17

IAS Symposium: Selected topics in science and technology

8-10 May 2017, IAS Building, Garching Campus

02.05.17

IAS Coffee Talk with PTL Florian Praetorius

3 May 2017, 1 pm, TUM IAS Building, Garching Campus

23.02.16

10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Friday, 09. June 2017
Workshop: Standing up for science
9 June 2017, 9am-4pm, Brussels
Apply now: McKinsey 'Forschergeist' symposium
9-11 June 2017, Berlin For doctoral researchers and postdocs!