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BioMat02 - LURACS

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Lubrication, Ageing and Recovery in Native Cartilage and Cartilage Substitutes

Cartilage has exceptional tribological properties, in particular at low sliding velocities – far from any synthetic material. In this project, we will investigate the mechanical behavior of native ovine cartilage over many length, time and force scales to understand how nature achieved these properties. Cartilage of different age will be sheared, compressed, dehydrated or chemically stressed and then investigated on various scales by macrorheology (MR), indentation measurements, and atomic force microscopy (AFM). We will directly quantify the friction processes taking place between two cartilage surfaces with friction AFM and MR tribology measurements. A special emphasize will be put on the role of the lubricant, which is synovial liquid in natural joints. In addition, we will monitor the flow of liquid in and out of cartilage during compression/ relaxation with fluorescence microscopy. By additionally using gain or loss of function principles and the combined multiscale approaches we will get unique insights into the ability of cartilage to recover its initial material properties and in the crucial molecular components for this behavior. Our approach will therefore pinpoint important bioinspired strategies on how to construct suitable cartilage substitutes. The project will be tightly integrated in the Focus Area Biomaterials. The unique combination of macro-, micro- and nanoscopic methods combined with the wide range of force and time scales studied will allow for a new quality in the understanding of the biomechanical properties of cartilage and guide the path to bio-inspired optimized cartilage substitutes.

01-01-1970
IGSSE setup of interdisciplinary research in project teams
16.05.17

Apply now: 12th call for proposals

IGSSE supports up to 10 new project teams

Call closes 2 July 2017

11.06.17

Apply now: IGSSE travel grant for ICCE 2017

28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017

08.06.17

IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

14.05.17

Climate-KIC: Join the PhD Catapult

Two-week thematic summer schools across Europe

04.05.17

IAS Symposium: Selected topics in science and technology

8-10 May 2017, IAS Building, Garching Campus

02.05.17

IAS Coffee Talk with PTL Florian Praetorius

3 May 2017, 1 pm, TUM IAS Building, Garching Campus

23.02.16

10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Friday, 09. June 2017
Workshop: Standing up for science
9 June 2017, 9am-4pm, Brussels
Apply now: McKinsey 'Forschergeist' symposium
9-11 June 2017, Berlin For doctoral researchers and postdocs!