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BioMat01 - AMMA

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A Multiscale Model of Atherosclerosis

Atherosclerosis precipitates sequelae such as angina, heart attack and stroke, among others, and therefore is heavily involved in the leading causes of death in the western world. During atherosclerotic lesion formation, leukocytes, fatty substances, cholesterol crystals, cellular waste, calcium, platelets and fibrinogen accumulate in and on the intima and media of arteries, resulting in arterial wall thickening and subsequently continuous narrowing of the vessel lumen. Atherosclerotic plaque may rupture and expose its thrombogenic contents to the blood stream, leading to massive local blood coagulation and formation of a thrombus. Such thrombosis may lead to local and/or distal obstruction of blood vessels and gives rise to a major part of acute coronary deaths worldwide. The mechanical impact from blood flow and pressure imposed on the artery wall during atherosclerosis progression, its consequences on plaque composition and inflammation as well as the process of lesion formation with its interplay with biomechanical conditions, however, remain to be conclusively addressed. In this project, a multiscale and multidisciplinary approach to the mechanobiology of atherosclerosis is taken that is based on computational techniques and experimental calibration and verification as well as in vivo molecular imaging. The biological processes involved take place at the (sub)cellular length scale and will be studied in low density lipoprotein-receptor deficient mice by means of immunohistochemistry, staining for inflammatory cell types and mediators. Serial histology slices will be registered to hybrid fluorescence molecular tomography/x-ray computed tomography images, which will allow to assess the regional distribution of involved cell types and molecular mediators. Based on the imaged 3D geometries, macroscopic computational fluid-solid interaction models with transport and diffusion of species and cells supply an understanding of the local mechanical conditions which can then be correlated to the biological findings. Including a longitudinal study of lesion formation will then allow to formulate hypotheses of functional relationships in the mechanobiology of atherosclerosis. A computational microscopic biological model will be implemented in a stochastic cellular potts model which will be coupled to the macroscopic continuum representation of the region of interest in a multiscale framework. Imaging of several stenoses in mice as well as carefully designed in vitro experiments are applied to test the hyphotheses of the model, calibrate its behavior and evaluate its predictive capabilities.

01-01-1970

 

12.07.17

EuroTech network event: From excellent research to excellent innovation – are universities ready for the future?

20 September 2017, 6-8pm, Representation of the Free State of Bavaria to the European Union,...

10.07.17

More fun than anyone: IGSSE@ TUM´s dragon boat race

Although the IGSSE team did not make it to Head of the Olympic Lake in 2017 - their fun was...

11.06.17

Apply now: IGSSE travel grant for ICCE 2017

28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017

23.02.16

10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Wednesday, 12. July 2017
Monday, 17. July 2017
Apply now: TUM-Imperial Global Fellows Summer School
17-21 July 2017, Burghausen, Germany
Wednesday, 19. July 2017
Wednesday, 26. July 2017
Register now: ICMSB 2017
26-28 July 2017, TUM Study and Science Center, Raitenhaslach