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9.02 Immunotherapies

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Development of combined bioinformatics and experimental efficacy and safety testing systems for immunotherapies using tumor reactive T cell receptors

The interaction of T-cell receptors (TCR) with major histocompatibility complex (MHC) class Imolecules and antigenic peptides (TCR-p-MHC) is highly important for the recognition ofvirus- or tumor-derived antigenic peptides by the adaptive immune system. We havepreviously identified a high number of potentially recognizable peptide epitopes derived fromprimary tumor samples as well as several TCR with specificity for some selected peptideligands, which may be useful for clinical application in diverse malignancies. However, despite intensive experimental testing, therapeutic application still harbors risks regardingsafety and efficacy. Improved understanding and modeling of the TCR-p-MHC interactionmay therefore be of high relevance. Using our designated expertise in computationalmethods of p-MHC interaction, we now plan to combine bioinformatics and experimentaltechniques for the development and optimization of cancer-specific TCR. We will focus onthe affinity prediction of peptides identified by immunopeptidomics to MHC in order tofacilitate the selection of most promising epitope candidates. Moreover, we will develop algorithms for TCR-p-MHC docking in order to predict peptide specificity of the TCR as well as mimotopes potentially recognized by selected TCR candidates. Such algorithms will potentially also allow optimization of TCR complementary determining regions (CDR) forenhanced specificity and function. Taken together, the project will be highly relevant forinvention of novel anti-tumor immunotherapies and impacts on efficacy, safety and economicaspects.

01-01-1970
IGSSE setup of interdisciplinary research in project teams
16.05.17

Apply now: 12th call for proposals

IGSSE supports up to 10 new project teams

Call closes 2 July 2017

11.06.17

Apply now: IGSSE travel grant for ICCE 2017

28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017

08.06.17

IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

14.05.17

Climate-KIC: Join the PhD Catapult

Two-week thematic summer schools across Europe

04.05.17

IAS Symposium: Selected topics in science and technology

8-10 May 2017, IAS Building, Garching Campus

02.05.17

IAS Coffee Talk with PTL Florian Praetorius

3 May 2017, 1 pm, TUM IAS Building, Garching Campus

23.02.16

10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Friday, 09. June 2017
Workshop: Standing up for science
9 June 2017, 9am-4pm, Brussels
Apply now: McKinsey 'Forschergeist' symposium
9-11 June 2017, Berlin For doctoral researchers and postdocs!