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6.02 Interdisciplinary Modeling of Biofilms

About

Nature tends to use the cheap and available materials at small length scales to build species, where viscoelasticity is a common practice. Biofilms, an abundant example of such species, are microbial communities consisting of microorganisms surrounded by an extracellular polymeric matrix (EPS). Biofilms are a preferred way of microbial existence as they provide protection against existing physical forces and chemical attack, if necessary. Formation of a biofilm is desirable in some cases (wastewater treatment, biochemical production), whereas in others it poses severe problems (marine equipment fouling, biomaterial-related infections). Biofilm architecture, mechanics and its interaction with surrounding fluid can have profound influence on their behavior and potential treatments, i.e. susceptibility to sloughing, and antibiotic resistance. Consequently, a better understanding of biofilms will require reliable experimental findings and detailed models that are capable of predicting biofilm architecture and growth, and their interaction with surrounding fluids.

In This work, we propose to design an experiment to measure the mechanical properties and characteristics of biofilms in situ in a novel microfluidic device by applying a finite load on the structure. In order to extract the viscoelastic material properties out of the experimental data, a modified version of the in‐house Finite Element Code will be used initially. Furthermore, The advanced viscoelastic material will be implemented in a state of the art Fluid-Structure Interaction (FSI) model to study the formation of complex biofilm structures, such as ripples and streamers. Though composed of microorganisms, a biofilm is a macro-scale structure that interacts with its environment as a macro-scale material. The findings in this proposed study will shed a light on the missing understanding of the macro-scale dynamic lives of bacterial aggregates living in complex interactive environments.

 

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01-01-1970
14.02.17

Registration now open: IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

18.04.17

Project team ROLITOS in a German documentary

10 May 2017, 11.30 pm Suedwestrundfunk (TV)

30 May 2017, 10.30 pm Bayerischer Rundfunk (TV)

11.04.17

Apply now: McKinsey 'Forschergeist' symposium

9-11 June 2017, Berlin

For doctoral researchers and postdocs!

10.04.17

Register now: ICMSB 2017

26-28 July 2017, TUM Study and Science Center, Raitenhaslach

30.03.17

Apply now: Bavarian Elite Support Act - Scholarship 2017

Universität Bayern e.V. awards 10 research scholarships to highly qualified junior scientists...

30.03.17

1st ExaHyPE Colloquium

3 April 2017, 1pm-5pm, Leibniz Supercomputing Centre, Garching Campus

14.02.17

Registration now open: IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

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ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Monday, 03. April 2017
1st ExaHyPE Colloquium
3 April 2017, 1pm-5pm, Leibniz Supercomputing Centre, Garching Campus