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10.09 VASCULAR MECHANOBIOLOGY

About

Mathematical and Molecular Foundations of Vascular Mechanobiology

The emerging field of mechanobiology, which focuses on biological responses by cells to mechanical stimuli, has revolutionized over the past two decades our understanding of growth and remodelling (G&R) in biological soft tissues. Nevertheless, most current mathematical models in this field suffer from an unsatisfactory experimental foundation and rely in many crucial aspects on heuristic assumptions. Moreover, their relationship to the underlying molecular foundations of mechanobiology remains in many aspects unclear.

In this project, we perform computer-controlled tissue culture experiments to establish the first general mathematical model of vascular G&R whose main assumptions (e.g. mechanobiological homeostasis and mechanobiological stability) will be based directly on relevant experimental observations. These tissue culture experiments – together with complementary in vivo and ex vivo experiments with wild-type and mutant mice – will allow us to relate elements of the said mathematical model to specific micromechanical and molecular mechanisms. The resulting comprehensive multiscale model of vascular mechanobiology will be focused toward computer-aided prognosis of aortic aneurysms in order to provide improved patient-specific predictions of lesion enlargement and rupture risk.

01-01-1970
14.02.17

Registration now open: IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

18.04.17

Project team ROLITOS in a German documentary

10 May 2017, 11.30 pm Suedwestrundfunk (TV)

30 May 2017, 10.30 pm Bayerischer Rundfunk (TV)

11.04.17

Apply now: McKinsey 'Forschergeist' symposium

9-11 June 2017, Berlin

For doctoral researchers and postdocs!

10.04.17

Register now: ICMSB 2017

26-28 July 2017, TUM Study and Science Center, Raitenhaslach

30.03.17

Apply now: Bavarian Elite Support Act - Scholarship 2017

Universität Bayern e.V. awards 10 research scholarships to highly qualified junior scientists...

30.03.17

1st ExaHyPE Colloquium

3 April 2017, 1pm-5pm, Leibniz Supercomputing Centre, Garching Campus

14.02.17

Registration now open: IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Monday, 03. April 2017
1st ExaHyPE Colloquium
3 April 2017, 1pm-5pm, Leibniz Supercomputing Centre, Garching Campus