Direkt zum Inhalt springen

10.09 VASCULAR MECHANOBIOLOGY

About

Mathematical and Molecular Foundations of Vascular Mechanobiology

The emerging field of mechanobiology, which focuses on biological responses by cells to mechanical stimuli, has revolutionized over the past two decades our understanding of growth and remodelling (G&R) in biological soft tissues. Nevertheless, most current mathematical models in this field suffer from an unsatisfactory experimental foundation and rely in many crucial aspects on heuristic assumptions. Moreover, their relationship to the underlying molecular foundations of mechanobiology remains in many aspects unclear.

In this project, we perform computer-controlled tissue culture experiments to establish the first general mathematical model of vascular G&R whose main assumptions (e.g. mechanobiological homeostasis and mechanobiological stability) will be based directly on relevant experimental observations. These tissue culture experiments – together with complementary in vivo and ex vivo experiments with wild-type and mutant mice – will allow us to relate elements of the said mathematical model to specific micromechanical and molecular mechanisms. The resulting comprehensive multiscale model of vascular mechanobiology will be focused toward computer-aided prognosis of aortic aneurysms in order to provide improved patient-specific predictions of lesion enlargement and rupture risk.

01-01-1970
14.02.17

IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

IGSSE setup of interdisciplinary research in project teams
16.05.17

Apply now: 12th call for proposals

IGSSE supports up to 10 new project teams

Call closes 2 July 2017

14.05.17

Climate-KIC: Join the PhD Catapult

Two-week thematic summer schools across Europe

04.05.17

IAS Symposium: Selected topics in science and technology

8-10 May 2017, IAS Building, Garching Campus

03.05.17

PhD position in project team INTERACT

Deadline for applications 15 June 2017

02.05.17

IAS Coffee Talk with PTL Florian Praetorius

3 May 2017, 1 pm, TUM IAS Building, Garching Campus

14.02.17

IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

20 < lib.tabbedcontent
May - 2017
Sun Mon Tue Wed Thu Fri Sat
  01
02
03
04
05 06
07 08 09
10
11 12 13
14
15
16
17
18
19
20
21 22
23
24 25 26 27
28
29
31  
Tuesday, 02. May 2017
IAS Coffee Talk with PTL Florian Praetorius
3 May 2017, 1 pm, TUM IAS Building, Garching Campus
Thursday, 04. May 2017
IAS Symposium: Selected topics in science and technology
8-10 May 2017, IAS Building, Garching Campus
Wednesday, 10. May 2017
Project team ROLITOS in a German documentary
10 May 2017, 11.30 pm Suedwestrundfunk (TV) 30 May 2017, 10.30 pm Bayerischer Rundfunk (TV)
Sunday, 14. May 2017
Climate-KIC: Join the PhD Catapult
Two-week thematic summer schools across Europe
Monday, 15. May 2017
Apply now: 12th call for proposals
IGSSE supports up to 10 new project teams Call closes 2 July 2017
Wednesday, 17. May 2017
Podiumsdiskussion: Frauenförderung - Quo vadis?
17. Mai 2017, 14- 16 Uhr, Hochschule Weihenstephan-Triesdorf, Weidenbach
Friday, 19. May 2017
Tuesday, 23. May 2017
Monday, 29. May 2017
IGSSE Forum 2017
29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen