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10.09 VASCULAR MECHANOBIOLOGY

About

Mathematical and Molecular Foundations of Vascular Mechanobiology

The emerging field of mechanobiology, which focuses on biological responses by cells to mechanical stimuli, has revolutionized over the past two decades our understanding of growth and remodelling (G&R) in biological soft tissues. Nevertheless, most current mathematical models in this field suffer from an unsatisfactory experimental foundation and rely in many crucial aspects on heuristic assumptions. Moreover, their relationship to the underlying molecular foundations of mechanobiology remains in many aspects unclear.

In this project, we perform computer-controlled tissue culture experiments to establish the first general mathematical model of vascular G&R whose main assumptions (e.g. mechanobiological homeostasis and mechanobiological stability) will be based directly on relevant experimental observations. These tissue culture experiments – together with complementary in vivo and ex vivo experiments with wild-type and mutant mice – will allow us to relate elements of the said mathematical model to specific micromechanical and molecular mechanisms. The resulting comprehensive multiscale model of vascular mechanobiology will be focused toward computer-aided prognosis of aortic aneurysms in order to provide improved patient-specific predictions of lesion enlargement and rupture risk.

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12.07.17

EuroTech network event: From excellent research to excellent innovation – are universities ready for the future?

20 September 2017, 6-8pm, Representation of the Free State of Bavaria to the European Union,...

10.07.17

More fun than anyone: IGSSE@ TUM´s dragon boat race

Although the IGSSE team did not make it to Head of the Olympic Lake in 2017 - their fun was...

11.06.17

Apply now: IGSSE travel grant for ICCE 2017

28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017

23.02.16

10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Wednesday, 12. July 2017
Monday, 17. July 2017
Apply now: TUM-Imperial Global Fellows Summer School
17-21 July 2017, Burghausen, Germany
Wednesday, 19. July 2017
Wednesday, 26. July 2017
Register now: ICMSB 2017
26-28 July 2017, TUM Study and Science Center, Raitenhaslach