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Improving Osteoporosis Diagnostics and Fracture Risk Prediction in osteoporotic Patients through the Assessment of Bone Quality

Osteoporosis is a bone degenerative disease that affects 1 in 3 women and 1 in 5 men worldwide. This disease causes more than 8.9 million fractures annually. In fact, osteoporotic patients often present fragility fractures as result of light trauma or even nontraumatic conditions. Both diagnostics and therapeutic options for osteoporotic patients present major limitations. Currently, the diagnosis of osteoporosis is based solely on the determination of bone mineral density (BMD). BMD-based diagnostic is often performed too late (i.e. when their osteoporosis is usually established or severe) and does not consider factors like bone geometry, microarchitecture, cortical porosity, tissue-level components, degree of mineralization and microdamage. All these factors have a demonstrated impact on bone strength and osteoporosis. One study will combine μCT, Raman microspectroscopy, histology and miRNA analysis to optimize diagnosis. The parameters obtained by these techniques will be associated in order to obtain a most complete dataset.
Furthermore, fractures in osteoporotic patients have a poor healing capacity. Tissue engineering approaches may be a highly promising means to treat fracture and bone defects in osteoporotic patients. miRNA modulating molecules will be complexed as dendrimers. The resulting dendriplexes will be loaded onto scaffolds. The in vitro  osteogenic potential will be tested. Subsequently, they will be investigated in a critical-sized femur defect model. The bone regenerate will be studied using the markers as used in the diagnostic study.

01-01-1970
IGSSE setup of interdisciplinary research in project teams
16.05.17

Apply now: 12th call for proposals

IGSSE supports up to 10 new project teams

Call closes 2 July 2017

11.06.17

Apply now: IGSSE travel grant for ICCE 2017

28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017

08.06.17

IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

14.05.17

Climate-KIC: Join the PhD Catapult

Two-week thematic summer schools across Europe

04.05.17

IAS Symposium: Selected topics in science and technology

8-10 May 2017, IAS Building, Garching Campus

02.05.17

IAS Coffee Talk with PTL Florian Praetorius

3 May 2017, 1 pm, TUM IAS Building, Garching Campus

23.02.16

10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Friday, 09. June 2017
Workshop: Standing up for science
9 June 2017, 9am-4pm, Brussels
Apply now: McKinsey 'Forschergeist' symposium
9-11 June 2017, Berlin For doctoral researchers and postdocs!