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10.05 GLUTAIL

About

Tailoring Small Molecules Using Glucosyltransferases

Plant secondary metabolites are an important source of active ingredients for food, cosmetic and pharmaceutical industry. They are frequently decorated with sugars resulting in both increased stability and water solubility of the glycoside product that also show unique targeting effects and altered activity when compared to the original scaffold. Glycosides are formed by the action of glycosyltransferases (GTs) which are a ubiquitous group of enzymes that catalyze the transfer of a sugar moiety from an activated sugar donor, usually UDP-glucose to acceptor molecules usually an alcohol. We developed a method for the targeted functional characterization of GT genes and succeeded in the identification of the first terpene GT genes from grapevine (Vitis vinifera) whose encoded proteins showed unprecedented monoterpenol GT activities and glucosylated a broad range of acceptors (e.g. geraniol, citronellol, nerol). Preliminary studies on laboratory scale proved that the novel genes are good candidates to develop a bioprocess for the production of small molecule glucosides with recombinant E. coli.

The goals of our project are the establishment of an efficient and scalable bioprocess for the production of whole-cell GT biocatalysts, the design of the biocatalytic process step for the production of small molecule glucosides (e.g. geranyl glucoside), and up-scale to a prototype scale.

01-01-1970
IGSSE setup of interdisciplinary research in project teams
16.05.17

Apply now: 12th call for proposals

IGSSE supports up to 10 new project teams

Call closes 2 July 2017

11.06.17

Apply now: IGSSE travel grant for ICCE 2017

28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017

08.06.17

IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

14.05.17

Climate-KIC: Join the PhD Catapult

Two-week thematic summer schools across Europe

04.05.17

IAS Symposium: Selected topics in science and technology

8-10 May 2017, IAS Building, Garching Campus

02.05.17

IAS Coffee Talk with PTL Florian Praetorius

3 May 2017, 1 pm, TUM IAS Building, Garching Campus

23.02.16

10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Friday, 09. June 2017
Workshop: Standing up for science
9 June 2017, 9am-4pm, Brussels
Apply now: McKinsey 'Forschergeist' symposium
9-11 June 2017, Berlin For doctoral researchers and postdocs!