Direkt zum Inhalt springen

10.01 4D-MSOT

About

Four-Dimensional Molecular Optoacoustic Tomography of Cardiovascular Function and Biology

In vivo optical imaging in the near-infrared (NIR) spectrum plays a significant role in cardiovascular research. To this end, non-invasive optical imaging of processes implicated in cardiovascular disease has been reported. For instance, visualization of macrophage infiltration using fluorescent nanoparticles and investigations of monocyte recruitment for infarct healing have been performed using Fluorescence Molecular Tomography (FMT). Clinical translation strategies include intravascular molecular imaging approaches with a NIR fluorescence (NIRF) catheter as a highly promising method for detecting biologic activity in atherosclerotic plaques. However, optical imaging methods are intrinsically limited in performance by tissue scattering, which degrades the spatial resolution and overall accuracy at increased penetration depths. Optoacoustic imaging approaches offer an efficient way of high resolution optical imaging through dense tissues. Furthermore, by applying multiple excitation wavelengths and tomographic signal detection, the Multi-Spectral Optoacoustic Tomography (MSOT) methods have been shown to resolve oxygenated and deoxygenated states of hemoglobin and deliver cross-sectional anatomical images of the mouse heart anatomy. In addition, MSOT detection of molecular imaging agents relevant to cardiovascular disease was demonstrated in murine hearts.

The ultimate goal of this team is to establish a novel high performance MSOT-based imaging platform tailored for realtime volumetric cardiovascular imaging in rodents. It will be able to simultaneously capture cardiac morphology, function and specific biological and molecular aspects of the heart disease using molecular nanosensors.

01-01-1970
14.02.17

Registration now open: IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

25.04.17

EuroTech postdoc workshop: Success in academia?

20-22 September 2017, Technical University of Denmark, Lynby Campus

18.04.17

Project team ROLITOS in a German documentary

10 May 2017, 11.30 pm Suedwestrundfunk (TV)

30 May 2017, 10.30 pm Bayerischer Rundfunk (TV)

11.04.17

Apply now: McKinsey 'Forschergeist' symposium

9-11 June 2017, Berlin

For doctoral researchers and postdocs!

10.04.17

Register now: ICMSB 2017

26-28 July 2017, TUM Study and Science Center, Raitenhaslach

14.02.17

Registration now open: IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

20 < lib.tabbedcontent
May - 2017
Sun Mon Tue Wed Thu Fri Sat
  02 03 04 05 06
07 08 09
10
11 12 13
14 15 16
17
18
19
20
21 22
23
24 25 26 27
28
29
30 31  
Wednesday, 10. May 2017
Project team ROLITOS in a German documentary
10 May 2017, 11.30 pm Suedwestrundfunk (TV) 30 May 2017, 10.30 pm Bayerischer Rundfunk (TV)
Wednesday, 17. May 2017
Podiumsdiskussion: Frauenförderung - Quo vadis?
17. Mai 2017, 14- 16 Uhr, Hochschule Weihenstephan-Triesdorf, Weidenbach
Friday, 19. May 2017
Tuesday, 23. May 2017
Monday, 29. May 2017
Registration now open: IGSSE Forum 2017
29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen