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10.01 4D-MSOT


Four-Dimensional Molecular Optoacoustic Tomography of Cardiovascular Function and Biology

In vivo optical imaging in the near-infrared (NIR) spectrum plays a significant role in cardiovascular research. To this end, non-invasive optical imaging of processes implicated in cardiovascular disease has been reported. For instance, visualization of macrophage infiltration using fluorescent nanoparticles and investigations of monocyte recruitment for infarct healing have been performed using Fluorescence Molecular Tomography (FMT). Clinical translation strategies include intravascular molecular imaging approaches with a NIR fluorescence (NIRF) catheter as a highly promising method for detecting biologic activity in atherosclerotic plaques. However, optical imaging methods are intrinsically limited in performance by tissue scattering, which degrades the spatial resolution and overall accuracy at increased penetration depths. Optoacoustic imaging approaches offer an efficient way of high resolution optical imaging through dense tissues. Furthermore, by applying multiple excitation wavelengths and tomographic signal detection, the Multi-Spectral Optoacoustic Tomography (MSOT) methods have been shown to resolve oxygenated and deoxygenated states of hemoglobin and deliver cross-sectional anatomical images of the mouse heart anatomy. In addition, MSOT detection of molecular imaging agents relevant to cardiovascular disease was demonstrated in murine hearts.

The ultimate goal of this team is to establish a novel high performance MSOT-based imaging platform tailored for realtime volumetric cardiovascular imaging in rodents. It will be able to simultaneously capture cardiac morphology, function and specific biological and molecular aspects of the heart disease using molecular nanosensors.

IGSSE setup of interdisciplinary research in project teams

Apply now: 12th call for proposals

IGSSE supports up to 10 new project teams

Call closes 2 July 2017


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28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017


IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen


Climate-KIC: Join the PhD Catapult

Two-week thematic summer schools across Europe


IAS Symposium: Selected topics in science and technology

8-10 May 2017, IAS Building, Garching Campus


IAS Coffee Talk with PTL Florian Praetorius

3 May 2017, 1 pm, TUM IAS Building, Garching Campus


10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen


10th IGSSE Forum

Smart cooperation - science and technology in, with and for society


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Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Friday, 09. June 2017
Workshop: Standing up for science
9 June 2017, 9am-4pm, Brussels
Apply now: McKinsey 'Forschergeist' symposium
9-11 June 2017, Berlin For doctoral researchers and postdocs!