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Recent years have seen a strong trend towards modeling and simulation in biomedical engineering, biomechanics, biofluids, and mechanobiology. Due to its significance, hemodynamics is one area of enforced activity in this respect, but despite all efforts undertaken so far, a number of very important questions that could lead to a real medical impact still remain open. The project has aimed at such questions and wanted to enhance rough magnetic resonance imaging data by detailed simulations of the interaction between blood flow and arterial wall in order to compute quantities such as internal and superficial vessel wall stress and thus to obtain early indicators of disease.

In the cardiovascular system the continuous interaction between blood flow and the arterial wall plays a crucial role. Plaque or aneurysm rupture occurs when hemodynamic blood pressure and thus internal plaque stress exceed a threshold that cannot be compensated by vessel wall deformation. Diseases such as atherosclerosis significantly change the vessel wall composition by incorporation of lipids, smooth muscle cells, and extracellular matrix, thereby locally changing the material properties. Magnetic resonance imaging (MRI) may help elucidating the interplay between blood flow and vessel wall stability by providing patient-specific data on regional blood flow, vessel wall geometry, and vessel wall deformability, but the resolution of these data, in particular of the vessel wall composition,

is limited. Refined mathematical models of the blood flow wall interaction in combination with efficient and robust numerical simulation methods, on the other hand, have the potential to enhance these patient-specific MRI data so that changes in wall composition and stress peaks can be identified at early stages. In this way, a real medical impact is achievable. Ingredients needed for such an approach are the best of medical imaging, arterial wall modeling and the most efficient, robust and reliable computational methods for fluid-structure interaction. With respect to the latter, we concentrated on partitioned methods and their stable and efficient realization as combined iterative processes that consist of up to three different iteration levels. To meet the overall goal, we built on a sound basis of expertise in all these areas and created a multidisciplinary thematic research group that works in joint and synergistic ways.

 

In the cardiovascular system the continuous interaction between blood flow and the arterial wall plays a crucial role. Plaque or aneurysm rupture occurs when hemodynamic blood pressure and thus internal plaque stress exceed a threshold that cannot be compensated by vessel wall deformation. Diseases such as atherosclerosis significantly change the vessel wall composition by incorporation of lipids, smooth muscle cells, and extracellular matrix, thereby locally changing the material properties.

Magnetic resonance imaging (MRI) may help elucidating the interplay between blood flow and vessel wall stability by providing patient-specific data on regional blood flow, vessel wall geometry, and vessel wall deformability, but the resolution of these data, in particular of the vessel wall composition, is limited. Refined mathematical models of the blood flow wall interaction in combination with efficient and robust numerical simulation methods, on the other hand, have the potential to enhance these patient-specific MRI data so that changes in wall composition and stress peaks can be identified at early stages. In this way, a real medical impact is achievable.

The ingredients needed for such an approach are the best of medical imaging, arterial wall modeling and the most efficient, robust and reliable computational methods for fluid-structure interaction. With respect to the latter, we concentrate on partitioned methods and their stable and efficient realization as combined iterative processes that consist of up to three different iteration levels.

01-01-1970
IGSSE setup of interdisciplinary research in project teams
16.05.17

Apply now: 12th call for proposals

IGSSE supports up to 10 new project teams

Call closes 2 July 2017

11.06.17

Apply now: IGSSE travel grant for ICCE 2017

28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017

08.06.17

IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

14.05.17

Climate-KIC: Join the PhD Catapult

Two-week thematic summer schools across Europe

04.05.17

IAS Symposium: Selected topics in science and technology

8-10 May 2017, IAS Building, Garching Campus

02.05.17

IAS Coffee Talk with PTL Florian Praetorius

3 May 2017, 1 pm, TUM IAS Building, Garching Campus

23.02.16

10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Friday, 09. June 2017
Workshop: Standing up for science
9 June 2017, 9am-4pm, Brussels
Apply now: McKinsey 'Forschergeist' symposium
9-11 June 2017, Berlin For doctoral researchers and postdocs!