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A successful osseointegration of orthopedic implants requires a strong mechanical interaction between the surface of the biomaterial and the surrounding natural bone tissue. This biological process is determined by initial cell-biomaterial interactions. In the last decades scientists in the fields of material science, surface engineering, chemistry, physics, biology, biochemistry and medicine attempted to functionalize the surfaces of implants with bioactive molecules in order to enable signaling to adjacent cells and to obtain a rapid and specific cell colonization directly on the material surface.

Mimicking the physiological adhesion process of osteoblasts to the extracellular matrix (ECM), by coating of implant surfaces with specific cell-adhesive molecules, was proven to enhance osteoblast adhesion in vitro and accelerate osseointegration of implants in vivo. Cell adhesion is mediated by integrins, a family of heterodimeric transmembrane glycoproteins, which regulate cell-ECM and cell-cell interactions. The peptide sequence Arg-Gly-Asp (RGD) is by far the most effective and extensively studied ligand to promote osteoblast adhesion and proliferation on implants through integrin stimulation.

The goal of this project is to optimize the biofunctionalization of different orthopedic implants with av-specific integrin ligands in order to develop clinically effective biomaterials for bone grafting in humans (see Figure). Each of the components of the coating system (implant material, anchor, spacer and specific integrin ligand) should be considered and studied in detail for the design of successful biomimetic materials.

01-01-1970
14.02.17

Registration now open: IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

25.04.17

EuroTech postdoc workshop: Success in academia?

20-22 September 2017, Technical University of Denmark, Lynby Campus

18.04.17

Project team ROLITOS in a German documentary

10 May 2017, 11.30 pm Suedwestrundfunk (TV)

30 May 2017, 10.30 pm Bayerischer Rundfunk (TV)

11.04.17

Apply now: McKinsey 'Forschergeist' symposium

9-11 June 2017, Berlin

For doctoral researchers and postdocs!

10.04.17

Register now: ICMSB 2017

26-28 July 2017, TUM Study and Science Center, Raitenhaslach

14.02.17

Registration now open: IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Wednesday, 10. May 2017
Project team ROLITOS in a German documentary
10 May 2017, 11.30 pm Suedwestrundfunk (TV) 30 May 2017, 10.30 pm Bayerischer Rundfunk (TV)
Wednesday, 17. May 2017
Podiumsdiskussion: Frauenförderung - Quo vadis?
17. Mai 2017, 14- 16 Uhr, Hochschule Weihenstephan-Triesdorf, Weidenbach
Friday, 19. May 2017
Tuesday, 23. May 2017
Monday, 29. May 2017
Registration now open: IGSSE Forum 2017
29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen