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A successful osseointegration of orthopedic implants requires a strong mechanical interaction between the surface of the biomaterial and the surrounding natural bone tissue. This biological process is determined by initial cell-biomaterial interactions. In the last decades scientists in the fields of material science, surface engineering, chemistry, physics, biology, biochemistry and medicine attempted to functionalize the surfaces of implants with bioactive molecules in order to enable signaling to adjacent cells and to obtain a rapid and specific cell colonization directly on the material surface.

Mimicking the physiological adhesion process of osteoblasts to the extracellular matrix (ECM), by coating of implant surfaces with specific cell-adhesive molecules, was proven to enhance osteoblast adhesion in vitro and accelerate osseointegration of implants in vivo. Cell adhesion is mediated by integrins, a family of heterodimeric transmembrane glycoproteins, which regulate cell-ECM and cell-cell interactions. The peptide sequence Arg-Gly-Asp (RGD) is by far the most effective and extensively studied ligand to promote osteoblast adhesion and proliferation on implants through integrin stimulation.

The goal of this project is to optimize the biofunctionalization of different orthopedic implants with av-specific integrin ligands in order to develop clinically effective biomaterials for bone grafting in humans (see Figure). Each of the components of the coating system (implant material, anchor, spacer and specific integrin ligand) should be considered and studied in detail for the design of successful biomimetic materials.

01-01-1970
IGSSE setup of interdisciplinary research in project teams
16.05.17

Apply now: 12th call for proposals

IGSSE supports up to 10 new project teams

Call closes 2 July 2017

11.06.17

Apply now: IGSSE travel grant for ICCE 2017

28-29 September 2017, TU Darmstadt

Submission deadline for abstracts: 18 June 2017

08.06.17

IGSSE Forum 2017

29-31 May 2017, TUM Science and Study Center Raitenhaslach, Burghausen

14.05.17

Climate-KIC: Join the PhD Catapult

Two-week thematic summer schools across Europe

04.05.17

IAS Symposium: Selected topics in science and technology

8-10 May 2017, IAS Building, Garching Campus

02.05.17

IAS Coffee Talk with PTL Florian Praetorius

3 May 2017, 1 pm, TUM IAS Building, Garching Campus

23.02.16

10th IGSSE Forum

1 - 4 June 2016, TUM Science and Study Center, Burghausen

05.06.16

10th IGSSE Forum

Smart cooperation - science and technology in, with and for society

15.12.15

The Science of Cooking

Doctoral Candidates explore the Secrets of a great Dinner

26.11.15

ATUMS@IGSSE

Having heard of a great Canadian Kick-Off Meeting, everyone at IGSSE was thrilled to welcome the...

20.11.15

Breakfast at IGSSE´s

Meet the IGSSE team every other month! All the things IGSSE members wanted to asked but never dared...

13.10.15

Save the Date: Canadian ATUMS Speaker on "Global Science- Global Career"

26. November 2015, 6-8 pm, IAS Faculty Club, Garching Campus

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Friday, 09. June 2017
Workshop: Standing up for science
9 June 2017, 9am-4pm, Brussels
Apply now: McKinsey 'Forschergeist' symposium
9-11 June 2017, Berlin For doctoral researchers and postdocs!